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Zen Itoh Selected Research

mitemcinal

9/2008Effects of mitemcinal (GM-611), an orally active erythromycin-derived prokinetic agent, on delayed gastric emptying and postprandial glucose in a new minipig model of diabetes.
7/2008Mitemcinal (GM-611), an orally active motilin receptor agonist, improves delayed gastric emptying in a canine model of diabetic gastroparesis.
4/2008Assessment of the carcinogenic potential of mitemcinal (GM-611): increased incidence of malignant lymphoma in a rat carcinogenicity study.
4/2008Effects of oral mitemcinal (GM-611), erythromycin, EM-574 and cisapride on gastric emptying in conscious rhesus monkeys.
1/2008Oral mitemcinal (GM-611), an erythromycin-derived prokinetic, accelerates normal and experimentally delayed gastric emptying in conscious dogs.
8/2007Hemodynamic and electrophysiological effects of mitemcinal (GM-611), a novel prokinetic agent derived from erythromycin in a halothane-anesthetized canine model.
1/2007Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs.

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Zen Itoh Research Topics

Disease

5Gastroparesis
09/2008 - 01/2007
3Dyspepsia (Indigestion)
03/2011 - 01/2007
2Torsades de Pointes (Torsade de Pointes)
08/2007 - 08/2007
1Body Weight (Weight, Body)
09/2008
1Hyperglycemia
09/2008
1Liver Failure
09/2008
1Renal Insufficiency (Renal Failure)
09/2008
1Lymphoma (Lymphomas)
04/2008
1Carcinogenesis
04/2008
1Cardiac Arrhythmias (Arrythmia)
08/2007
1Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
01/2007

Drug/Important Bio-Agent (IBA)

7mitemcinalIBA
09/2008 - 01/2007
3Cisapride (Propulsid)FDA Link
07/2008 - 08/2007
1ThiazolesIBA
03/2011
1Z 338IBA
03/2011
1Pharmaceutical PreparationsIBA
03/2011
1Glucose (Dextrose)FDA LinkGeneric
09/2008
1Insulin (Novolin)FDA Link
09/2008
1Streptozocin (Streptozotocin)FDA Link
09/2008
1motilin receptorIBA
07/2008
1MotilinIBA
04/2008
1Erythromycin (Erycette)FDA LinkGeneric
08/2007

Therapy/Procedure

1Intravenous Injections
09/2008